Crossing the barriers: Revisiting the gut feeling in rheumatoid arthritis

To avoid autoimmunity, it is essential to keep the balance between defence against pathogens and maintenance of tolerance self-antigens. Mucosal inflammation may lead breakdown activation autoreactive cells. Growing evidence suggests a major contribution gut microbiota onset chronic, autoimmune inflammatory diseases including rheumatoid arthritis (RA). RA patients show significant differences in composition compared healthy controls, murine models certain bacteria can induce Th17 responses or autoantibody production. The plays an important role regulating immunogenic tolerogenic immune responses. intestinal barrier site body where most host–microbiota interaction takes place. Certain their metabolites cause break homeostasis by affecting integrity permeability. However, intact separate epithelium from toxins, microorganisms, antigens lumen. This review will focus on correlation leaky arthritis. Furthermore, be discussed how targeting function dietary changes might provide opportunity modulate development RA.